17. The structure of KRAS G12C bound to divarasib highlights features of potent switch-II pocket engagement.
Small GTPases. 2025.
Fernando MC, Craven GB, Shokat KM.
16. Mutant-selective AKT inhibition via lysine targeting and neo-zinc chelation.
Nature. 2025.
Craven GB, Chu H, Sun JD, Carelli JD, Coyne B, Chen H, Chen Y, Ma X, Das S, Kong W, Zajdlik AD, Yang KS, Reisberg SH, Thompson PA, Lipford JR, Taunton J.
15. Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network.
J Am Chem Soc. 2024.
Weaver J, Craven GB, Tram L, Chen H, Taunton J.
14. Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.
Nat Chem. 2023.
Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J.
13. Signal peptide mimicry primes Sec61 for client-selective inhibition.
Nat Chem Biol. 2023.
Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO.
12. CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery.
Nat Microbiol. 2022.
Benns HJ, Storch M, Falco JA, Fisher FR, Tamaki F, Alves E, Wincott CJ, Milne R, Wiedemar N, Craven GB, Baragaña B, Wyllie S, Baum J, Baldwin GS, Weerapana E, Tate EW, Child MA.
11. Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A.
J Biol Chem. 2022.
Liu Y, De Castro Ribeiro O, Haapanen O, Craven GB, Sharma V, Muench SP, Goldman A.
10. Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
Nat Chem Biol. 2022.
Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD, Niessen S, Burlingame AL, Carelli JD, Taunton J.
9. Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.
Acta Pharm Sin B. 2022.
Qin B, Craven GB, Hou P, Chesti J, Lu X, Child ES, Morgan RML, Niu W, Zhao L, Armstrong A, Mann DJ, Cui S.
8. Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
RSC Med Chem. 2022.
Jamshidiha M, Hogg TL, Sutherell CL, Craven GB, Tersa M, De Vita E, Brustur D, Hassan S, Petracca R, Morgan RML, Sanz-hernández M, Norman JC, Armstrong A, Mann DJ, Tate EW.
7. Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides.
J Org Chem. 2021.
Craven GB, Briggs EL, Zammit CM, McDermott A, Greed S, Affron DP, Leinfellner C, Cudmore HR, Tweedy RR, Luisi R, Bull JA, Armstrong A.
6. Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
ChemBioChem. 2020.
Craven GB, Affron DP, Kösel T, Wong TLM, Jukes ZH, Liu CT, Morgan RML, Armstrong A, Mann DJ.
5. Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening.
Bio-Protocol. 2020.
Craven GB, Mann DJ, Armstrong A.
4. Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy.
MedChemComm. 2019.
Craven GB, Affron DP, Raymond PN, Mann DJ, Armstrong A.
3. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery.
Angew Chem Int Ed. 2018.
Craven GB, Affron DP, Allen CE, Matthies S, Greener JG, Morgan RML, Tate EW, Armstrong A, Mann DJ.
2. Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)–H functionalization of amines.
Chem Sci. 2018.
Idiris FIM, Majesté CE, Craven GB, Jones CR.
1. Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity.
Nat Commun. 2016.
Alguel Y, Amilis S, Leung J, Lambrinidis G, Capaldi S, Scull NJ, Craven GB, Iwata S, Armstrong A, Mikros E, Diallinas G, Cameron AD, Byrne B.