Selected Publications

Lysine-targeted covalent inhibitor design

Mutant-selective AKT inhibition via lysine targeting and neo-zinc chelation.
Nature. 2025.
Craven GB, Chu H, Sun JD, Carelli JD, Coyne B, Chen H, Chen Y, Ma X, Das S, Kong W, Zajdlik AD, Yang KS, Reisberg SH, Thompson PA, Lipford JR, Taunton J.

AKT figure

Chemoproteomic probe screening

Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes.
Nat Chem. 2023.
Chen Y, Craven GB, Kamber RA, Cuesta A, Zhersh S, Moroz YS, Bassik MC, Taunton J.

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Synthesis of novel electrophiles for drug discovery

Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides.
J Org Chem. 2021.
Craven GB, Briggs EL, Zammit CM, McDermott A, Greed S, Affron DP, Leinfellner C, Cudmore HR, Tweedy RR, Luisi R, Bull JA, Armstrong A.

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Fragment-based covalent inhibitor design

Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT).
ChemBioChem. 2020.
Craven GB, Affron DP, Kösel T, Wong TLM, Jukes ZH, Liu CT, Morgan RML, Armstrong A, Mann DJ.

covSAR